发明名称 ADJUSTMENT OF SIDE CHAIN VARIANT AND ENERGY BIOMARKER OF REDOX-ACTIVE THERAPY FOR TREATMENT OF MITOCHONDRIAL DISEASE AND OTHER SYMPTOMS
摘要 PROBLEM TO BE SOLVED: To provide a method for treating a mitochondrial disorder, adjusting one or more energy biomarkers, normalizing one or more energy biomarkers, or strengthening one or more energy biomarkers.SOLUTION: Disclosed are not only the treatment method or inhibiting method for mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's hereditary optic neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactic acidosis, strokelike symptoms (MELAS), or Kearns-Sayre syndrome (KSS), but also a useful compound in the method. A useful method and compound for treatment of other diseases are disclosed. An energy biomarker useful for evaluation of a subject's metabolic state and the effect of the treatment is also disclosed. In addition to the method for adjusting, normalizing, or strengthening the energy biomarker, a compound useful in such a method is also disclosed.SELECTED DRAWING: None
申请公布号 JP2016047854(A) 申请公布日期 2016.04.07
申请号 JP20160000208 申请日期 2016.01.04
申请人 EDISON PHARMACEUTICALS INC 发明人 MILLER GUY M;HECHT SIDNEY M;JANKOWSKI ORION D;WESSON KIERON E;PAUL MOLLARD
分类号 A61K31/05;A61K31/122;A61P3/10;A61P9/00;A61P9/10;A61P21/00;A61P21/02;A61P25/00;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P27/02;A61P35/00;A61P43/00;C07C50/04;C07C50/06 主分类号 A61K31/05
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