发明名称 ENANTIOSELECTIVE SYNTHESIS OF DIALKYLATED N,O-HETEROCYCLES BY PALLADIUM-CATALYZED ALLYLIC ALKYLATION
摘要 This invention provides enantioenriched N,O-heterocyclic compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I):;;comprising treating a compound of formula (II):;;with a transition metal catalyst under alkylation conditions.
申请公布号 US2016096810(A1) 申请公布日期 2016.04.07
申请号 US201514877496 申请日期 2015.10.07
申请人 Stoltz Brian M.;Numajiri Yoshitaka;Behenna Douglas C. 发明人 Stoltz Brian M.;Numajiri Yoshitaka;Behenna Douglas C.
分类号 C07D265/32;C07D265/36;C07D265/10;C07D261/04;C07D265/02;C07D267/04;C07D279/12;C07D263/18 主分类号 C07D265/32
代理机构 代理人
主权项 1. A compound represented by formula (I), R1 represents hydrogen or optionally substituted alkyl, cycloalkyl, (cycloalkyl)alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, alkenyl, alkynyl, —C(O)alkyl, —C(O)aryl, —C(O)aralkyl, —C(O)heteroaryl, —C(O)heteroaralkyl, —C(O)O(alkyl), —C(O)O(aryl), C(O)O(aralkyl), —C(O)O(heteroaryl), or —C(O)O(heteroaralkyl); or R2 represents hydrogen or substituted or unsubstituted alkyl, aralkyl, aryl, heteroaralkyl, heteroaryl, alkenyl, alkynyl, or halo; R7, R8, R9, and R10 are independently selected for each occurrence from hydrogen, hydroxyl, halogen, nitro, alkyl, alkenyl, alkynyl, cyano, carboxyl, sulfate, amino, alkoxy, alkylamino, alkylthio, hydroxyalkyl, alkoxyalkyl, aminoalkyl, thioalkyl, ether, thioether, ester, amide, thioester, carbonate, carbamate, urea, sulfonate, sulfone, sulfoxide, sulfonamide, acyl, acyloxy, acylamino, aryl, heteroaryl, carbocyclyl, heterocyclyl, aralkyl, arylalkoxy, heteroaralkyl, carbocyclylalkyl, and heterocyclylalkyl; W1, W2, and W3 are independently selected for each occurrence from CR11R12, O, and S; R11 and R12 are independently selected for each occurrence from hydrogen, hydroxyl, halogen, nitro, alkyl, alkenyl, alkynyl, cyano, carboxyl, sulfate, amino, alkoxy, alkylamino, alkylthio, hydroxyalkyl, alkoxyalkyl, aminoalkyl, thioalkyl, ether, thioether, ester, amide, thioester, carbonate, carbamate, urea, sulfonate, sulfone, sulfoxide, sulfonamide, acyl, acyloxy, acylamino, aryl, heteroaryl, carbocyclyl, heterocyclyl, aralkyl, arylalkoxy, heteroaralkyl, carbocyclylalkyl, and heterocyclylalkyl; wherein any occurrence of may optionally combine with any second occurrence of or an occurrence of R12, along with the carbons to which they are attached, to form an optionally substituted 3-8 membered ring; and n is an integer from 0-3; wherein the compound of formula (I) is not
地址 San Marino CA US