| 发明名称 |
DIRECT ANTI-MARKOVNIKOV ADDITION OF ACIDS TO ALKENES |
| 摘要 |
A method of making an anti-Markovnikov addition product, comprises reacting an acid with an alkene or alkyne in a dual catalyst reaction system to the exclusion of oxygen to produce said anti-Markovnikov addition product; the dual catalyst reaction system comprising a single electron oxidation catalyst in combination with a hydrogen atom donor catalyst. Dual catalyst composition useful for carrying out such methods are also described. |
| 申请公布号 |
US2016096791(A1) |
申请公布日期 |
2016.04.07 |
| 申请号 |
US201414787179 |
申请日期 |
2014.05.02 |
| 申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
Nicewicz David A.;Hamilton David S. |
| 分类号 |
C07C41/05;C07C67/00;B01J35/00;C08F4/00;C07B37/02;B01J31/02;C07D325/00;C08F2/00 |
主分类号 |
C07C41/05 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of making an anti-Markovnikov addition product, comprising:
reacting an acid with an alkene or alkyne in a dual catalyst reaction system to the exclusion of oxygen to produce said anti-Markovnikov addition product; said dual catalyst reaction system comprising a single electron oxidation catalyst in combination with a hydrogen atom donor catalyst; wherein said hydrogen atom donor catalyst is a compound of the Formula A-SH, where A is alkyl, aryl, or an electron withdrawing group. |
| 地址 |
Chapel Hill NC US |
