发明名称 |
SULFAMIDE LINKER, CONJUGATES THEREOF, AND METHODS OF PREPARATION |
摘要 |
The present invention relates to a compound comprising an alpha-end and an omega-end, the compound comprising on the alpha-end a reactive group Qlcapable of reacting with a functional group F1present on a biomolecule and on the omega-end a target molecule, the compound further comprising a group according to formula (1) or a salt thereof: Said compound may also be referred to as a linker-conjugate. The invention also relates to a process for the preparation of a bioconjugate, the process comprising the step of reacting a reactive group Q1of a linker-conjugate according to the invention with a functional group F1of a biomolecule. The invention further relates to a bioconjugate obtainable by the process according to the invention. In a preferred embodiment, the invention concerns a process for the preparation of a bioconjugate via a cycloaddition, such as a (4+2)-cycloaddition (e.g. a Diels-Alder reaction) or a (3+2)-cycloaddition (e.g. a 1,3-dipolar cycloaddition). |
申请公布号 |
WO2016053107(A1) |
申请公布日期 |
2016.04.07 |
申请号 |
WO2015NL50697 |
申请日期 |
2015.10.05 |
申请人 |
SYNAFFIX B.V. |
发明人 |
VERKADE, JORGE MERIJN MATHIEU;WIJDEVEN, MARIA ANTONIA;VAN DE SANDE, PETRUS JOSEPHUS JACOBUS MARIA;VAN BERKEL, SANDER SEBASTIAAN;VAN DELFT, FLORIS LOUIS |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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