发明名称 |
A 1,4,5-TRISUBSTITUTED1,2,3-TRIAZOLE MIMETIC OF RGD and/or OGP10-14, PROCESS TO OBTAIN IT AND USES THEREOF |
摘要 |
The present invention relates to nonpeptide compounds of formula (I) which are mimetics of RGD (Arg-Gly-Asp) and/or, OGP 10-14 (Tyr-Gly-Phe-Gly-Gly), osteogenic peptides, containing a central 1,4,5-trisubstituted 1,2,3-triazole core and a reactive appendage appropriate to form covalent "click" bonds on the surface of materials functionalized with reactive groups including: azide, terminal alkyne, cyclooctalkyne, thiol, maleimide or thiolacid groups and to a process for the preparation of RGD and OGP 10-14 mimetics containing a 1,4,5-trisubstituted 1,2,3-triazole core. These nonpeptide mimetics are particularly useful for medical devices, in particular implants and tissue engineering and cell culture matrices. |
申请公布号 |
EP2749298(B1) |
申请公布日期 |
2016.04.06 |
申请号 |
EP20120382535 |
申请日期 |
2012.12.26 |
申请人 |
UNIVERSIDAD DEL PAIS VASCO-EUSKAL HERRIKO UNIBERTSITATEA;FUNDACIÓN TECNALIA RESEARCH & INNOVATION;CENTRO DE INVESTIGACIÓN BIOMEDICA EN RED EN BIOINGENIERIA, BIOMATERIALES Y NANOMEDICINA |
发明人 |
AIZPURUA IPARRAGUIRRE, JESÚS, Mª;SAGARTZAZU AIZPURUA, MAIALEN;BRACERAS IZAGUIRRE, IÑIGO;AZPIROZ DORRONSORO, FRANCISCO, JAVIER;OYARBIDE VICUNA, JOSEBA;FERNANDEZ OYON, XAVIER |
分类号 |
A61L27/00;A61K31/4192;C07D249/04 |
主分类号 |
A61L27/00 |
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