发明名称 |
PROCESS FOR PURIFYING CYCLIC LIPOPEPTIDE COMPOUNDS OR SALTS THEREOF |
摘要 |
A process for purifying cyclic lipopeptide compounds or salts thereof comprising the steps of: (1) charging a crude compound of Formula I onto a macroporous adsorption resin; (2) washing the macroporous adsorption resin using water, an organic solvent or a mixed solution of an organic solvent and water as a washing liquid; and (3) eluting the compound of Formula I from the macroporous adsorption resin using water, an organic solvent or a mixed solution of an organic solvent and water as an eluent. The purification method has the advantages of using a small amount of organic solvents, using no silica gel, and causing little damage to the environment; the purity of the collected compound of formula I is also improved as compared with the methods previously disclosed. |
申请公布号 |
EP2623511(B1) |
申请公布日期 |
2016.04.06 |
申请号 |
EP20110828114 |
申请日期 |
2011.09.27 |
申请人 |
SHANGHAI TECHWELL BIOPHARMACEUTICAL CO., LTD |
发明人 |
ZHANG, ZHAOLI;LIU, SHIDONG;ZHUO, ZHONGHAO;JI, XIAOMING |
分类号 |
C07K7/56 |
主分类号 |
C07K7/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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