Method of vaccination for limiting articular inflammation in rheumatoid arthritis and multiple sclerosis by administering IL-23 peptides

摘要

The present invention relates to a pharmaceutical composition comprising as active substance, at least one compound comprising, or consisting of, a polypeptide which comprises, or consists of, at least 11 contiguous amino acids selected from X1-S-D-I-F-X2-G-E-P-X3-L-X4-P-X5-X6-X7-X8-X9-Q-L (SEQ ID NO: 13).

主权项

1. A method of vaccination for protecting against articular inflammation in rheumatoid arthritis and multiple sclerosis, comprising administering to a subject in need thereof a compound comprising or consisting of a cyclized polypeptide to a subject in need thereof, wherein the cyclized polypeptide comprises a sequence having at least 90% identity with SEQ ID NO:2 and has a length equal to or less than 28 amino acid residues, or consists of a sequence having at least 90% identity with SEQ ID NO:2, and elicits antibodies directed against human IL-23.