Synthesis, methods of using, and compositions of cycloalkylmethylamines

摘要

The present invention provides novel cycloalkylmethylamine analogs, and methods of preparing cycloalkylmethylamine analogs. The present invention also provides methods of using cycloalkylmethylamine analogs and compositions of cycloalkylmethylamine analogs. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications.

主权项

1. A cycloalkylmethylamine derivative of structural Formula (IV): or a pharmaceutically acceptable salt thereof, wherein: n is 1; SP is a spacer selected from the group consisting of propylene, methylpropylene, and butylene; X is O, S, or NH; R2 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl; R4 is hydrogen, alkyl, or substituted alkyl; R5 is hydrogen, alkyl, halogen, hydroxyl, or alkoxy; R6 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl; and R7 is hydrogen, alkyl, halogen, hydroxyl, or alkoxy; wherein substituted means that one or more hydrogen atoms of the chemical moiety are each independently replaced with halogen, alkyl, alkoxy, or amino.