| 发明名称 | Methods and materials for treating cancer | ||
| 摘要 | This document provides methods and materials involved in treating cancer. For example, methods and materials for identifying a mammal as having an elevated level of PD-1+/CD11ahigh CD8 T cells having the potential to exert anti-cancer effects are provided. In addition, methods and materials for identifying a mammal as having an elevated level of PD-1+/CD11ahigh CD8 T cells and administering a PD-1 inhibitor to such a mammal are provided. | ||
| 申请公布号 | US9302005(B2) | 申请公布日期 | 2016.04.05 |
| 申请号 | US201414192376 | 申请日期 | 2014.02.27 |
| 申请人 | Mayo Foundation for Medical Education and Research | 发明人 | Dong Haidong;Kwon Eugene D.;Markovic Svetomir N.;Krco Christopher J. |
| 分类号 | A61K45/00;C07K14/705;A61K35/17 | 主分类号 | A61K45/00 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. A method for treating a mammal having cancer, wherein said method comprises: (a) identifying said mammal as having an elevated level of PD-1+/CD11ahigh CD8 T cells within a blood, body fluid, or tumor samplerelative to a reference level of PD-130 /CD11ahigh CD8 T cells in mammals without cancer, and (b) administering a PD-1 inhibitor to said mammal, wherein naturally-occurring tumor-reactive CD8 CTLs within a PD-1+/CD11ahigh CD8 T cell population of said mammal exert an anti-cancer effect against said cancer. | ||
| 地址 | Rochester MN US | ||