Anti-adipogenic compositions containing <i>Piper betle </i>and <i>Dolichos biflorus</i>

摘要

Herbal compositions are useful for inhibition, amelioration or prevention of adipogenesis mediated diseases such as obesity, lipid storage disease and hyperlipemia. The herbal compositions comprise biologically effective amounts of extracts or fractions from Piper betle in combination with one or more of the extracts or fractions derived from Dolichos biflorus, Commiphora mukul, Boerhaavia diffusa, Tribulus terrestris and Zingiber officinale as active ingredients. The compositions optionally contain a bio-enhancing agent or a bio-protecting agent, along with biologically acceptable carriers or diluents. The herbal compositions may be used in a method for treating or preventing adipogenesis involved diseases in mammals.

主权项

1. An oral dosage form, comprising:
an amount of an anti-adipogenic herbal composition which is effective for inhibiting or ameliorating adipogenesis in mammals, said herbal composition comprising: from 33% to 67% by weight of a Piper betle extract, wherein the Piper betle extract is obtained by extraction of Piper betle with a solvent selected from the group consisting of:
an alcoholic solvent containing 40% to 60% water, anda polar organic solvent selected from the group consisting of C3-C4 alcohols and C3-C6 ketones; and an effective amount of a Dolichos biflorus extract, wherein the Dolichos biflorus extract is obtained by extraction of Dolichos biflorus with a solvent selected from the group consisting of at least one polar organic solvent and a combination of a polar organic solvent and water, optionally in combination with at least one biologically acceptable excipient; wherein said dosage form is a tablet, soft capsule, hard capsule, pill, controlled release tablet, or polymer-coated tablet.