Systems and methods for freezing, storing and thawing biopharmaceutical materials

摘要

A system for using freezing, storing and thawing biopharmaceutical materials which includes a holder and a container for holding biopharmaceutical materials therein. The holder has a cavity and the container is received in the cavity. The holder includes a first portion and second portion. The container is received between the first portion and the second portion to connect the container to the holder. The holder includes an interior cradle having a bottom and edges extending from the bottom. The cradle bounds the cavity. An outer rim is connected to the cradle and separated from the cavity. The bottom includes an inner surface facing the cavity receiving the container and an outer surface. The outer surface of the bottom is recessed relative to an outer surface of the outer rim.

主权项

1. A system for use in freezing, storing and thawing biopharmaceutical materials, said system comprising:
a container configured to contain biopharmaceutical materials therein; a holder having a cavity, said container received in said cavity; said holder comprising a first portion and a second portion forming an interior cradle, said container received between said first portion and said second portion to connect said container to said holder; said first portion having a first bottom and first edges extending from said first bottom and forming a first inner rim, said first bottom and said first edges bounding said cavity, said inner rim extending completely around a perimeter of said container, said first inner rim comprising longitudinal sides, ends, and curved corners surrounding said perimeter, each of said corners connecting a longitudinal side of said longitudinal sides to an end of said ends, said container contacting said first bottom, said first edges, and at least one corner of said corners; said first edges comprising curved surfaces having first edge axes about perpendicular to axes of said curved corners; said second portion comprising a second bottom bounding said cavity opposite said first bottom and second edges extending from said second bottom and bounding said cavity, said second edges comprising second curved surfaces having second edge axes about perpendicular to said axes of said curved corners, said container contacting said second bottom and said second edges; said first portion comprising an outer rim connected to said cradle and separated from said cavity and said inner rim; and wherein said first bottom comprises an inner surface facing said cavity receiving said container and an outer surface, said outer surface of said first bottom being recessed towards said container relative to an outermost surface of said outer rim such that said outermost surface is located further away from said second portion than said outer surface of said bottom is located away from said second portion.