发明名称 |
LONG-ACTING POLYMERIC PRODRUGS OF EXENDIN |
摘要 |
Long-acting polymer exendin-4 or exendin agonist derivatives of the formula Pol-L-E are provided wherein Pol is a polymer, L is a releasing linker undergoing slow autohydrolysis and E is an exendin or exendin agonist. Theseexendin or exendin agonists are slowly released from Pol-L upon administration to a living organism. The derivatives are useful e.g. for the treatment of diabetes mellitus. |
申请公布号 |
CA2689909(C) |
申请公布日期 |
2016.04.05 |
申请号 |
CA20082689909 |
申请日期 |
2008.06.05 |
申请人 |
ASCENDIS PHARMA AS |
发明人 |
RAU, HARALD;HERSEL, ULRICH;VETTER, DIRK;WEGGE, THOMAS |
分类号 |
A61K47/48;A61K38/26;A61P3/10;A61P5/50;A61P25/28;C07K14/605 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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