发明名称 |
CONDITIONAL CYTOTOXIC GENE THERAPY VECTOR FOR SELECTABLE STEM CELL MODIFICATION FOR ANTI HIV GENE THERAPY |
摘要 |
A method, system, and apparatus for treating a patient with HIV. A vector can be modified from a thymidine kinase gene. The modified vector is expressed in the presence of tat RNA. The modified vector is then package and delivered to HIV-infected cells. The replication of HIV is inhibited by eliminating infected cells in the presence of Ganciclovir. Modified cells are then selected utilizing transient tat RNA transfection and GFP expression. Vector-modified stem cells are then selected for transplantation back into the patient, thereby producing a normal immune system in the patient when the modified vector remains dormant in the absence of HIV tat. |
申请公布号 |
WO2016018664(A3) |
申请公布日期 |
2016.03.31 |
申请号 |
WO2015US41146 |
申请日期 |
2015.07.20 |
申请人 |
TEXAS TECH UNIVERSITY SYSTEM;GARG, HIMANSHU;JOSHI, ANJALI |
发明人 |
GARG, HIMANSHU;JOSHI, ANJALI |
分类号 |
C12N15/867;A61K48/00;C07K14/035 |
主分类号 |
C12N15/867 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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