DRUG DELIVERY DEVICE INCLUDING ELECTROLYTIC PUMP

摘要

Systems and methods are provided for a drug delivery device and use of the device for drug delivery. In various aspects, the drug delivery device combines a “solid drug in reservoir” (SDR) system with an electrolytic pump. In various aspects an improved electrolytic pump is provided including, in particular, an improved electrolytic pump for use with a drug delivery device, for example an implantable drug delivery device. A catalytic reformer can be incorporated in a periodically pulsed electrolytic pump to provide stable pumping performance and reduced actuation cycle.

主权项

1. A drug delivery device, comprising:
a pump and a reservoir associated with the pump, the pump being an electrolytic pump including a chamber and a plurality of electrodes positioned within the chamber, the plurality of electrodes configured to be coupled to a power supply such that at least one of the electrodes is configured as an anode and at least another of the electrodes is configured as a cathode, the chamber being a sealed chamber configured to hold an electrolyte, the chamber having a side including a flexible impermeable membrane, the pump further including a reformer positioned within the chamber, the reformer configured to recombine gases generated by the electrolytic pump from an electrolyte contained within the chamber, the reservoir positioned in association with the membrane of the pump, and the reservoir configured to receive a drug in solid form and having an orifice configured to allow bodily fluid to pass through the orifice into the reservoir and to allow bodily fluid including the drug to be expelled from the reservoir upon deflection of the membrane.