Attenuated streptococcus suis vaccines and methods of making and use thereof

摘要

The present invention provides an attenuated Streptococcus suis (S. suis) vaccine strain capable of providing a safe and protective immune response in porcine against S. suis or diseases caused by S. suis; wherein the strain comprises at least three mutated virulence gene(s), coding for polypeptide(s) having one or more amino acid substitutions relative to the corresponding polypeptide(s) in the strain’s corresponding virulent parental S. suis strain; and wherein the at least three genes are rpsL-S12 (a 30S ribosomal subunit protein), an ABC transporter ATP binding membrane protein (ABC-ATPBMP) and marR transcription regulator.