发明名称 |
骨障害及び/又は心血管障害の治療又は診断に使用する組成物 |
摘要 |
The invention relates to methods for diagnosing bone disorders and/or cardiovascular disorders in a subject, by contacting a biological sample from the subject with (a) a nucleic acid molecule which hybridizes to miR-31 or its 5 or 3′ isoforms or variants, or (b) an agent that binds to miR-31 or its 5′ or 3′ isoforms or variants; detecting and evaluating the hybridization signal of the nucleic acid molecule or agent with a polynucleotide or said miR-31 or its 5′ or 3′ isoforms or variants; and comparing the detected and evaluated hybridization or binding signal with that of a control sample, wherein a stronger hybridization signal or a stronger binding signal in the sample of the subject compared to that of the control sample is indicative for a risk of developing or having a bone disorder and/or cardiovascular disorder. |
申请公布号 |
JP5894581(B2) |
申请公布日期 |
2016.03.30 |
申请号 |
JP20130511636 |
申请日期 |
2011.05.23 |
申请人 |
ウニヴェルズィテート・フューア・ボーデンクルトゥーア・ウィーン |
发明人 |
グリラリ,ヨハネス;シュラムル,エリーザベト;フォルトシェッガー,クラウス;グリラリ,レジーナ |
分类号 |
A61K31/711;A61K31/713;A61P7/02;A61P9/00;A61P9/04;A61P9/10;A61P9/12;A61P13/12;A61P19/08;A61P19/10;A61P25/28;A61P43/00;C12Q1/68;G01N33/53 |
主分类号 |
A61K31/711 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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