发明名称 Benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions thereof, and their use in methods for treating cancer
摘要 Chemical entities that are benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions and methods of treatment of cancer are described.
申请公布号 US9295671(B2) 申请公布日期 2016.03.29
申请号 US201213594634 申请日期 2012.08.24
申请人 NEUPHARMA, INC. 发明人 Zhu Yong-Liang;Qian Xiangping
分类号 A61K31/498;A61K31/5377;C07D401/04;C07D403/04;C07D413/04;C07D241/42;C07D241/44;A61K31/18;A61P35/00;A61P35/02;G01N33/574;C12Q1/68 主分类号 A61K31/498
代理机构 Wilson Sonsini Goodrich & Rosati 代理人 Wilson Sonsini Goodrich & Rosati
主权项 1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen, cyano, halogen, optionally substituted lower alkyl, optionally substituted alkoxy, optionally substituted amino, optionally substituted aryl, optionally substituted heterocycloalkyl, or optionally substituted heteroaryl; R2, R3, R4, and R5 are hydrogen; R6, R7, R8, and R10 are independently hydrogen, cyano, sulfanyl, or halo; R9 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; and R11 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl.
地址 Foster City CA US