| 发明名称 | Serum amyloid P derivatives and their preparation and use | ||
| 摘要 | One aspect of the present invention relates to the surprising discovery that modification of a glycan structure on a human SAP polypeptide can increase the biological activity of the SAP polypeptide relative to a corresponding sample of wild-type SAP isolated from human serum. The disclosure provides both variant human SAP polypeptides and methods for making the same. In particular, the present invention provides methods and compositions for in vitro and in vivo addition, deletion, or modification of sugar residues to produce SAP polypeptides, such as a human SAP polypeptide, having a desired glycosylation pattern. | ||
| 申请公布号 | US9296800(B2) | 申请公布日期 | 2016.03.29 |
| 申请号 | US201012794132 | 申请日期 | 2010.06.04 |
| 申请人 | Promedior, Inc. | 发明人 | Willett W. Scott;Caimi Richard J. |
| 分类号 | C07K14/47;A61K38/00 | 主分类号 | C07K14/47 |
| 代理机构 | Ropes & Gray LLP | 代理人 | Ropes & Gray LLP ;Rones Melissa S.;Gummow Brian M. |
| 主权项 | 1. A glycosylated human Serum Amyloid P (SAP) protein comprising an N-linked oligosaccharide chain, wherein at least one branch of the N-linked oligosaccharide chain terminates with an α2,3-linked sialic acid moiety, wherein the SAP protein comprises a polypeptide comprising the amino acid sequence of SEQ ID NO: 1 or variant thereof, and wherein the SAP protein inhibits the differentiation of monocytes into fibrocytes in vitro. | ||
| 地址 | Lexington MA US | ||