PROCESSES FOR PREPARING FORM 1 ZD1839 POLYMORPH

摘要

The invention concerns processes for preparing certain crystalline solvates and hydrates of the compound of the Formula (I): (see formula I) which is known inter alia by way of the code number ZD1839. The processes are: (i) (a) washing Form 3 ZD1839 DMSO solvate with a solvent or solvent mixture substantially to remove dimethyl sulphoxide; and (b) isolating the Form 1 ZD1839 polymorph so formed; or (ii) (a) washing Form 2 ZD1839 MeOH solvate with a solvent or solvent mixture substantially to remove methanol; and (b) isolating the Form 1 ZD1839 polymorph so formed; or (iii) (a) washing a compound of Formula I substantially in the form of Form 5 ZD1839 trihydrate with a solvent or solvent mixture substantially to remove water; and (b) isolating the Form 1 ZD1839 polymorph so formed; or (iv) heating a compound of Formula I substantially in the form of Form 5 ZD1839 trihydrate for a sufficient time and at sufficient temperature to drive off water and effect transformation to Form 1 ZD1839 polymorph.