| 发明名称 | Use of an aromatase inhibitor for the treatment of hypogonadism and related diseases | ||
| 摘要 | The aromatase inhibitor 4,4′-[fluoro-(1-H-1,2,4-triazol-1-yl)methylene]bisbenzonitrile increases testosterone levels and treats hypogonadism and related diseases. A particular dosing regimen is disclosed as well as pharmaceutical compositions comprising said of 4,4′-[fluoro-(1-H-1,2,4-triazol-1-yl)methylene]bisbenzonitrile, optionally in combination with other active ingredients and kits comprising the pharmaceutical compositions. | ||
| 申请公布号 | US9295668(B2) | 申请公布日期 | 2016.03.29 |
| 申请号 | US201214342810 | 申请日期 | 2012.09.06 |
| 申请人 | Merco BioPharma 2 Limited | 发明人 | Taylor Ann;Klickstein Lloyd B. |
| 分类号 | A61K31/4196;A61K9/48 | 主分类号 | A61K31/4196 |
| 代理机构 | Wolff IP, a Prof. Corp. | 代理人 | Wolff IP, a Prof. Corp. ;Wolff, Esq. Jessica R. |
| 主权项 | 1. A method for the treatment of hypogonadotropic hypogonadism in an overweight or obese male patient with serum total testosterone levels below 400 ng/dl and in need of increased testosterone levels comprising administering to said patient an effective amount of the compound 4,4′-[fluoro-(1-H-1,2,4-triazol-1-yl)methylene]bisbenzonitrile, wherein the effective amount of the compound is from about 0.01 mg to about 1.0 mg per dose, and wherein the compound is administered according to a dosing regimen having a dosing periodicity selected from about one dose once weekly to about one dose once every month. | ||
| 地址 | London GB | ||