Prosthesis having varied concentration of beneficial agent

摘要

An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The interventional device has a controlled local areal density of beneficial agent for systemic delivery or delivery to the luminal wall. The local areal density of beneficial agent may be varied along the prosthesis. The interventional device includes overlapping or bifurcated stents having a controlled areal density of beneficial agent.

主权项

1. An interventional device for delivery of a beneficial agent, the interventional device comprising:
a first prosthesis capable of being deployed in a lumen, wherein at least a first portion of the first prosthesis has a first controlled local areal density of a beneficial agent, the first controlled local areal density varying as a continuous gradient along at least a length of the first portion of the first prosthesis; a second prosthesis configured to be connected to the first prosthesis, capable of being deployed in an overlapping relationship with the first prosthesis, wherein at least a second portion of the second prosthesis has a second controlled local areal density of a beneficial agent, the second controlled local areal density varying as a continuous gradient along at least the second portion of the second prosthesis; the first prosthesis and the second prosthesis, in combination, defining at least one non-overlapping segment and an overlapping segment, and the overlapping segment corresponding to the second portion overlapping the first portion and the overlapping segment having a length equal to the length of the first portion; and the first controlled local areal density of the first portion of the first prosthesis and the second controlled local areal density of the second portion of the second prosthesis providing in combination a varying amount of beneficial agent in a desired pattern over at least the length of the overlapping segment.