SALTS, CO-CRYSTALS, AMORPHOUS FORMS, AND CRYSTALLINE FORMS OF AN ARGININE METHYLTRANSFERASE INHIBITOR

摘要

Provided herein are solid forms (e.g., salts, co-crystals, amorphous forms, and crystalline forms) of N 1-((3-((5s,8s)-3,3-dimethyl-1-oxaspiro[4.5]decan-8-yl)-1H-pyrazol-4- yl)methyl)-N 1,N 2-dimethylethane-1,2-diamine (compound 133). Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve the solid forms for inhibiting arginine methyltransferase activity and for treating arginine methyltransferase-mediated disorders (e.g., proliferative disorders, neurological disorders, autoimmune disorders, vascular disorders, and metabolic disorders).