| 摘要 |
The disclosure describes methods of synthesis of phosphoramidate ester derivatives. Also disclosed are morphic forms of (S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(5-deutero-2,4- dioxo-3,4-dihydropyrimidin- 1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2- yl)dideuteromethoxy)-(phenoxy)phosphoryl)amino)propanoate and antiviral therapy using (S)- isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(5-deutero-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4- dihydroxy-4-methyltetrahydrofuran-2-yl)dideuteromethoxy)(phenoxy)phosphoryl)amino)- propanoate (e.g., anti-HCV therapies). |
