| 发明名称 |
TETRAHYDROISOQUINOLINES AS SELECTIVE NADPH OXIDASE 2 INHIBITORS |
| 摘要 |
Embodiments of bridged tetrahydroisoquinolines and methods for their use in selectively inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 are disclosed. The disclosed compounds have a structure according to general formula I or a pharmaceutically acceptable salt thereof:;;wherein “” represents a single or double bond, R1 is hydrogen, halogen, lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; Ra is hydrogen, —CH2R2, R3, or —SO2R4; R2 is lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R3 is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R4 is lower aliphatic, or substituted or unsubstituted aryl; and R5 is hydrogen, halogen, or lower aliphatic. |
| 申请公布号 |
US2016083351(A1) |
申请公布日期 |
2016.03.24 |
| 申请号 |
US201414888390 |
申请日期 |
2014.05.01 |
| 申请人 |
PAGANO Patrick J.;WIPF Peter;CIENFUENTES-PAGANO Maria E.;SKODA Erin M. |
发明人 |
Pagano Patrick J.;Wipf Peter;Cifuentes-Pagano Maria E.;Skoda Erin M. |
| 分类号 |
C07D221/22;A61K45/06;C07D409/06;C07D405/10;C07D413/06;A61K31/4748;C07D401/06 |
主分类号 |
C07D221/22 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A compound having a structure according to general formula I or a pharmaceutically acceptable salt thereof:wherein “” represents a single or double bond;
R1 is hydrogen, halogen, lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; Ra is hydrogen, —CH2R2, R3, or —SO2R4; R2 is lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R3 is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R4 is lower aliphatic, or substituted or unsubstituted aryl; and R5 is hydrogen, halogen, or lower aliphatic, provided that: when R1 is bromo or hydrogen, then Ra is not hydrogen. |
| 地址 |
US |
