The present disclosure provides methods for sensitizing a cell for modulation by oligomeric compounds. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell.
申请公布号
WO2016044840(A1)
申请公布日期
2016.03.24
申请号
WO2015US51236
申请日期
2015.09.21
申请人
IONIS PHARMACEUTICALS, INC.
发明人
KOLLER, ERICH;DONNER, AARON, J.;SETH, PUNIT, P.;BENNETT, C., FRANK