Surface modification for coating

摘要

A modified medical device substrate surface designed to improve adhesion of biomimetic surfactants to the medical device surface, thus reducing the risk of thrombosis is described. The surface modification is accomplished through either an application of a tie layer of a hydrophobic material on the substrate surface intermediate the biomimetic coating or through incorporation of a hydrophobic dopant in the polymeric substrate prior to extrusion or molding. Either method creates a hydrophobically modified surface that enhances the biomimetic surfactant bonding strength.

主权项

1. A substrate, which comprises:
a) a substrate composed of a material selected from the group consisting of silicone, polyether block amide (PEBA), polycarbonate and polyurethane, wherein the substrate has a surface; b) a hydrophobic tie layer having opposed top and bottom tie layer surfaces and a surface contact angle greater than about 40°, wherein the hydrophobic tie layer consists of a solvent and an unsaturated carboxylic acid amide at a concentration from about 0.1 to about 10 weight percent within the solvent; and c) a biomimetic surfactant comprising an alkyl chain, wherein the hydrophobic tie layer is positioned between the substrate surface and the biomimetic surfactant; and d) wherein the unsaturated carboxylic acid amide within the hydrophobic tie layer hydrophobically bonds to the alkyl chain of the biomimetic surfactant along the tie layer top surface and the unsaturated carboxylic acid amide hydrophobically bonds to the substrate surface along the tie layer bottom surface.