Systems and methods for vessel reactivity to guide diagnosis or treatment of cardiovascular disease

摘要

Systems and methods are disclosed for using vessel reactivity to guide diagnosis or treatment for cardiovascular disease. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; determining, by measurement or estimation, a first vessel size at one or more locations of a vessel of the patient-specific vascular model at a first physiological state; determining a second vessel size at the one or more locations of the vessel of the patient-specific vascular model at a second physiological state using a simulation or learned information; comparing the first vessel size to the corresponding second vessel size; and estimating a characteristic of the vessel of the patient-specific vascular model based on the comparison.

主权项

1. A computer-implemented method of estimating vessel wall characteristics, the method comprising:
receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; determining a first vessel size at a location of a vessel of the patient at a first physiological state; determining a model of a mechanical response of a vessel wall of the patient-specific vascular model at a second physiological state, the second physiological state being different from the first physiological state; determining, based on the determined mechanical response of the vessel wall at the second physiological state, a second vessel size at a location of the patient-specific vascular model corresponding to the location of the determined first vessel size, the second vessel size being associated with the second physiological state; comparing the first vessel size to the second vessel size; and estimating an active or passive material characteristic of the vessel wall of the patient-specific vascular model based on the comparison.