Surface binding of nanoparticle based drug delivery to tissue

摘要

Microparticles and nanoparticles and compositions thereof are provided. The microparticles and nanoparticles and compositions may be used for the treatment of musculoskeletal disease, such as osteoarthritis and injury.

主权项

1. A method for delivering a first active agent to a connective tissue in a subject, comprising
administering to a subject, a microparticle having an average particle size of greater than 10 nm and less than or equal to 500 nm, wherein the microparticle is comprised of a connective tissue binding peptide that is not gelatin, wherein the connective tissue binding peptide has a net positive charge, wherein the net positive charge is due at least in part to lysines and arginines in the connective tissue binding peptide, and wherein the microparticle includes a first active agent, wherein the first active agent is delivered to the connective tissue as it is released from the microparticle, wherein the first active agent is a therapeutic agent for the treatment of a musculoskeletal disease or injury; and further comprising administering to the subject a nanoparticle comprising a peptide having an average particle size of 1-10 nm.