Furyl and thienyl triazole derivatives and therapeutic uses thereof

摘要

Nitric oxide biosynthesis-inhibiting anti-inflammatory and anti-microbial compounds of Formula (3) and Formula (4) wherein R1 and R2 are independently selected from optionally substituted thienyl, optionally substituted furyl, optionally substituted —CH═CH-thienyl and optionally substituted —CH═CH-furyl, provided that R2 is substituted with as nitro group;
Treatment methods utilizing the compounds, and methods of synthesis of the compounds are also disclosed.

主权项

1. A compound of Formula (4): wherein R1 is thien-2-yl and R2 is 5-nitrothien-2-yl, or R1 is 4-hydroxyphenyl and R2 is 5-nitrothien-2-yl.