| 发明名称 |
OCULAR IMPLANT MADE BY A DOUBLE EXTRUSION PROCES |
| 摘要 |
The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release. |
| 申请公布号 |
US2016074418(A1) |
申请公布日期 |
2016.03.17 |
| 申请号 |
US201514949454 |
申请日期 |
2015.11.23 |
| 申请人 |
Allergan, Inc. |
发明人 |
Shiah Jane-Guo;Bhagat Rahul;Blanda Wendy M.;Nivaggioli Thierry;Peng Lin;Chou David;Weber David A. |
| 分类号 |
A61K31/573;A61K9/16;A61K9/00;A61F9/00 |
主分类号 |
A61K31/573 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A bioerodible implant for treating an ocular condition comprising particles of an active agent dispersed within a biodegradable polymer matrix, wherein
at least 75% of the particles of the active agent have a diameter of less than 20 μm, the biodegradable polymer comprises poly(lactic-co-glycolic)acid (PLGA) copolymer, the ratio of lactic to glycolic acid monomers in the PLGA copolymer is 50/50 weight percentage, and the bioerodible implant is prepared by milling the biodegradable polymer and subjecting the active agent and the biodegradable polymer to a double extrusion process. |
| 地址 |
Irvine CA US |
