NOVEL PRODRUG OF STEROIDAL CYP17 INHIBITOR/ANTIANDROGEN

摘要

PROBLEM TO BE SOLVED: To provide prodrugs of C-17-heterocyclic-steroidal drugs providing improved oral bioavailability and pharmacokinetics.SOLUTION: The present invention provides a prodrug compound represented by the formula I. The compound is an effective inhibitor of human CYP 17 enzyme. (X is benzimidazole; and Y is a sulfonyl or an alkylcarboxyl with a phosphoric acid).SELECTED DRAWING: None