| 摘要 |
PROBLEM TO BE SOLVED: To provide modified saccharides.SOLUTION: Provided are: modified capsular saccharides comprise a blocking group at a hydroxyl group position on at least one of the monosaccharide units of the corresponding native capsular saccharide, wherein the blocking group is of the formula (Ia) or (Ib): -O-X-Y (Ia) or -O-R(Ib), where X is C(O), S(O) or SO, Y is NRRor R, Ris Calkyl substituted with 1, 2 or 3 groups independently selected from hydroxyl, sulphydryl and amine, Ris H or Calkyl, and Ris Calkyl; processes for modifying a capsular saccharide with the blocking groups; saccharide-protein conjugates comprising the modified capsular saccharide; processes for making the saccharide-protein conjugates, pharmaceutical compositions comprising the modified capsular saccharides and/or saccharide-protein conjugates; and methods and uses of the same.SELECTED DRAWING: None |
