ALBUMIN VARIANTS

摘要

The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin.

主权项

1. A variant of albumin comprising a substitution in a position corresponding to position 500 in the amino acid sequence of SEQ ID NO:2, wherein the substitution is selected from the group consisting of K500A,C,D,E,F,G,H,I, L,M,N,Q,R,S,T,V,W, and Y, and wherein the variant has at least 90% sequence identity to the amino acid sequence of SEQ ID NO:2.