DISPENSING SYSTEM

摘要

The invention provides systems and methods for controlled dispensing of topical analgesics contained in a metered dispensing system. The systems and method are useful for treating signs and symptoms of osteoarthritis. The method includes depressing a hand pump to dispense a dose of a topical pain reliever in a viscous solution from the hand pump, wherein the hand pump is configured to dispense the dose within a tolerance specified by a corresponding label approved by a government regulatory agency; and spreading the topical solution on skin.

主权项

1. A method for treating pain of osteoarthritis of the knee of a patient in need thereof, the method comprising:
applying a therapeutically effective amount of a solution of diclofenac sodium to the knee of said patient, wherein said solution has a viscosity of between 500-3000 centipoise, wherein said applying comprises dispensing said solution from a pharmaceutically acceptable hand pump and spreading the solution onto the skin of said knee, and wherein said application provides
a mean Cmax of diclofenac of about 10.0 ng/mL to about 25.0 ng/mL;a mean Cmax of diclofenac at steady state of about 12.0 ng/mL to about 30.0 ng/mL; and/ora mean AUC0-12 of diclofenac of about 60.0 nghr/mL to about 140.0 nghr/mL.