| 摘要 |
The present invention describes new pyridopyrimidine derivatives compounds with structure represented by General Formula (I):;;or pharmaceutically acceptable salts thereof, or their mixtures (in any ratio), a pharmaceutical composition containing them, a method for using the new pyridopyrimidine derivatives compounds as inhibitor of the cyclic nucleotide synthesis or as inhibitor of the cAMP and cGMP synthesis, and their uses in the prophylactic and/or curative treatment of diarrhea, colitis and irritable bowel syndrome. |
| 主权项 |
1. A compound represented by General Formula (I):or pharmaceutically acceptable salts thereof, or their mixtures in any ratio, wherein:
R1 is selected from the group consisting of C1-6 alkyl, amino C1-6 alkyl, dimethylamino C1-6 alkyl, halo C1-6 alkyl, guanidino C1-6 alkyl, and mercapto C1-6 alkyl; R2 is selected from the group consisting of 4-(trifluoromethyl)thiophene, 3-fluoro-5-trifluoromethylphenyl, 3,5 -bistrifluoromethylphenyl, 1,3-benzodioxol-4-yl, 1,3-benzodioxol-5 -yl, 2,1,3-benzothiadiazol-4-yl, 2,1,3-benzothiadiazol-5 -yl, and substituted aryl wherein the substituent is selected from the group consisting of C1-6 alkoxy, halogen, C1-6 heteroar alkyl or C2-6 heteroaralkenyl; and X is selected from the group consisting of O, S and Se. |
