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1. A polypeptide comprising LAREYKKIVEKLKRWLRQVLRTLR (SEQ ID NO:1), or a variant of thereof,
said polypeptide having antimicrobial, antibacterial, antiviral, antifungal, antiparasitic and/or anti-inflammatory activity, said variant having at least 16 amino acids and:
having up to 5 of the following amino acid substitutions:
substitution of one or more amino acids selected from the group consisting of L, I, V or A by another amino acid selected from said group;substitution of one or more amino acids selected from the group consisting of R, K or H by another amino acid selected from said group;substitution of E by-Q Q;substitution of Y or W by F; andsubstitution of one or more amino acids selected from the group consisting of Q, N, A, S or T by another amino acid selected from said group;having one or more substitutions of an amino acid by a corresponding D-amino acid,having one or more substitutions of an amino acid by a corresponding non-natural amino acid, and/orhaving a retro-inverso sequence of at least 16 consecutive amino acids from said amino acid sequence. |
