发明名称 |
PARTICLES OF SPHERICALLY AGGLOMERATED LACTOSE FOR DIRECT COMPRESSION AND METHOD OF PREPARATION THEREOF |
摘要 |
Many active pharmaceutical ingredients are not directly compressible, therefore addition of pharmaceutical excipients is necessary. Fillers are essential pharmaceutical excipients, among which sugars are commonly employed, especially lactose. It is required that such substances have good flowability and compressibility. The present invention enables a simple and industry applicable production of particles of spherically agglomerated lactose that have suitable flow properties, excellent compression characteristics and reduce or prevent occurrence of segregation in mixture for production of solid dosage forms. They are porous spherical agglomerates. Particles of spherically agglomerated lactose comprise prism-like primary particles that are radially arranged and form a bigger agglomerate structure. Particles of spherically agglomerated lactose have suitable size, are highly breakable, have relatively high specific surface area and enable production of tablets with high tensile strength. |
申请公布号 |
WO2016039698(A1) |
申请公布日期 |
2016.03.17 |
申请号 |
WO2015SI00029 |
申请日期 |
2015.09.10 |
申请人 |
LAMEŠIĆ, DEJAN;LAVRIČ, ZORAN;ILIĆ, LLIJA |
发明人 |
LAMEŠIĆ, DEJAN;LAVRIČ, ZORAN;ILIĆ, LLIJA;PLANINŠEK, ODON |
分类号 |
A61K47/26;A61K9/14;A61K9/20;A61K31/00 |
主分类号 |
A61K47/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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