发明名称 |
COMPOSITIONS AND METHODS FOR MODIFYING IN VIVO CALCIFICATION OF HYDROGELS |
摘要 |
Provided herein according to some embodiments of the invention are methods of inhibiting or preventing calcification of hydrogels. Such methods may include combining the hydrogel with a buffer solution having a pH lower than 7.4; forming hydrogel by crosslinking alginate in a solution comprising a bisphosphonate compound; and/or forming hydrogel by crosslinking polyanionic polymer with a polyvalent cation that is not Ca2+. Compositions that may be used in such methods are also provided herein. Also provided herein according to some embodiments of the invention are methods of bone regeneration and/or formation that include administering hydrogel that does not encapsulate biological material that affects calcification and/or bone formation to an area of a subject's body that is in need of bone formation and/or regeneration. |
申请公布号 |
US2016074557(A1) |
申请公布日期 |
2016.03.17 |
申请号 |
US201514698257 |
申请日期 |
2015.04.28 |
申请人 |
Georgia Tech Research Corporation |
发明人 |
Schwartz Zvi;Lee Christopher S.D.;Moyer Hunter R.;Boyan Barbara |
分类号 |
A61L27/20;A61L27/38;A61L27/52 |
主分类号 |
A61L27/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Atlanta GA US |