| 摘要 |
The invention relates to the field of immunology and vaccinology, in particular to Respiratory Syncytial Virus (RSV) virosomes, and vaccines comprising them. Provided is an RSV virosome comprising (i) lipids and proteins extracted from the membrane of Respiratory Syncytial Virus; (ii) synthetic adjuvant chosen from PHAD (phosphorylated hexaacyl disaccharide) and the 3-O-desacyl derivate thereof, 3-D-PHAD; (iii) at least one synthetic or essentially pure phosphatidylcholine (PC) species and at least one synthetic or essentially pure phosphatidylethanolamine (PE) at a molar ratio of 3:1 to 1:3, characterized in that the acyl chains have between 4 and 18 carbon atoms, the total number of unsaturated bonds in the acyl chains being four, and that the molar ratio of total synthetic phospholipid to adjuvant is between 1.5 and 10; (iv) sterol or sterol derivative at a ratio of 0-30 mol% of total added phospholipid; and (v) optionally, one or more further antigens. |
