发明名称 |
New in vitro blood brain barrier model |
摘要 |
The invention is in the domain of delivery of molecules to brain cells across the blood-brain barrier. The invention relates to a novel polypeptide-based carrier that allows the efficient delivery of an effector peptide, to neuron cells across the blood-brain barrier, and to methods for the production and testing of such carrier, including a model for testing the capacity of such molecule to cross the blood-brain barrier and / or the toxicity of molecules on the blood brain barrier and/or the capacity of molecules that have crossed to target human brain cells (e/g. neurons, astrocytes and microglial cells). |
申请公布号 |
EP2995949(A1) |
申请公布日期 |
2016.03.16 |
申请号 |
EP20140306389 |
申请日期 |
2014.09.09 |
申请人 |
INSTITUT PASTEUR;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE |
发明人 |
PREHAUD, CHRISTOPHE;LAFON, MONIQUE;CECCALDI, PIERRE-EMMANUEL;AFONSO, PHILIPPE;LAFAYE, PIERRE |
分类号 |
G01N33/50;C12M3/00;C12N5/071;C12N5/079 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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