| 摘要 |
The present invention relates to the use of a compound for the manufacture of a medicament for the treatment of a bacterial infection, said compound being a compound of formula A pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof or a N- oxide form thereof, wherein R1 is hydrogen, halo, polyhalo C1-6alkyl, C1-6alkyl, hydroxy C1-6alkyl, C1-6alkyloxy, ar or Het, p is an integer equal to 1 or 2, R2 is C1-6 alkyloxy, C1-6alkyloxyC1-6alkyloxy or C1-6 alkylthio, R3 is C1-6alkyl, Ar, Het or Het1, R4 and R5 each independently are hydrogen, C1-6alkyl or benzyl, or R4 and R5 together and including the N to which they are attached may form a radical selected from the group of pyrrolidinyl, 2, pyrrolinyl, 3- pyrrolinyl, pyrrolyl, imidazolidinyl, pyrazolidinyl, 2- imidazolinyl, 2- pyrazolinyl, imidazolyl, pyrazolyl, triazolyl, piperidinyl, pyridinyl, piperazinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, morpholinyl and thiomorpholinyl, each of said rings may optionally be substituted with c1-6alkyl, halo, polyhaloC1-6alkyl, hydroxy, hydroxyC1-6alkyl, C1-6alkyloxy, amino, mono-or di(C1-6alkyl) amino, C1-6alkylthio, C1-6alkyloxyC1-6alkyl, C1-6alkylthioC1-6alkyl or pyrimidinyl, R6 is hydrogen, halo , polyhaloc1-6alkylC1-6alkyl, C1-6alkyloxy, C1-6alkythio, or two vicinal R6 radicals may be taken together to form a bivalent radical of formula –CH=CH-CH=CH-, r is an integer equal to 1 or 2, R7 is hydrogen, C1-6alkyl, Ar, Het or Het1, provided that the bacterial infection is other than a Mycobacterial infection |
