Multi-dimentional ion mobility separator method and apparatus

摘要

One aspect of the present invention is to extract multiple ionic species in a FAIMS into one or more IMS drift tubes simultaneously. By adjusting FAIMS operational parameters, ions in FAIMS are detected on IMS detectors through separation in FAIMS and/or separation and collection in the IMS. This method provides a continuous separation of specific ions from an ion swarm by employing a high-field differential mobility analyzer (FAIMS) with a plurality of orthogonal transitions paths spaced incrementally along the electrodes which allow additional separation by a conventional IMS drift tube. The components of the sample can be collected or detected.

主权项

1. An apparatus for the separation of components in a sample comprising:
(a) a differential ion mobility spectrometer with a plurality of outlets substantially orthogonal to a first sample flow path, wherein the outlets are located before the end of the separation section of the differential ion mobility spectrometer; (b) a plurality of time of flight ion mobility spectrometers simultaneously receiving ions leaving from the outlets; and (c) a plurality of ion accumulators in fluid communication with the time of flight ion mobility spectrometer and positioned to receive ions leaving the time of flight ion mobility spectrometer.