发明名称 Hydrazinyl Lipidoids and Uses Thereof
摘要 The present disclosure is directed to hydrazinyl lipidoids, formulations thereof further comprising at least one active agent, as well as methods of delivering the at least one active agent to a target organism.
申请公布号 US2016066569(A1) 申请公布日期 2016.03.10
申请号 US201514844952 申请日期 2015.09.03
申请人 Preceres Inc. 发明人 Heidebrecht, JR. Richard Wayne;Zhong Cheng
分类号 A01N25/12;C07D231/08;C12N15/113;A61K9/16;A61K31/713;C07C243/14;A01N57/16 主分类号 A01N25/12
代理机构 代理人
主权项 1. A compound of formula (I): wherein: R1 is, independently, hydrogen, an optionally substituted C1-20 aliphatic group, or an optionally substituted C1-20 heteroaliphatic group; R2 is, independently, an optionally substituted C1-20 aliphatic group or an optionally substituted C1-20 heteroaliphatic group; RA is hydrogen, an optionally substituted C1-20 aliphatic group, an optionally substituted, C1-20 heteroaliphatic group, or a group of formula (II): whereinR3 is, independently, hydrogen, an optionally substituted C1-20 aliphatic group, or an optionally substituted C1-20 heteroaliphatic group; andR4 is, independently, an optionally substituted C1-20 aliphatic group or an optionally substituted C1-20 heteroaliphatic group; RB is an optionally substituted aryl group, an optionally substituted heteroaryl group, or a group of formula (II): wherein R3 and R4 are as defined above; and wherein any one or more of R1, R2, R3, and R4 together with another R1, R2, R3, or R4 or one of RA and RB optionally defines a carbocyclic or heterocyclic ring system; and RA and RB together optionally define a carbocyclic or heterocyclic ring system.
地址 Cambridge MA US