发明名称 |
Method for the production of 18F-labeled PSMA-specific PET-tracers |
摘要 |
Novel efficient, time-saving and reliable radiofluorination procedures for the production of 18 F-labelled active esters via nucleophilic substitution of the corresponding onium precursors with 18 F - are described. The active ester including [ 18 F]F-Py-TFP and [ 18 F]TFB produced by one of these methods was used to prepare PSMA-specific PET tracers such as [ 18 F]DCFPyL. The key advantages of these inventive methods are efficiency, short time of preparation and excellent amenability to automation. A pharmaceutical composition containing at least one PSMA-specific PET tracers prepared by the inventive method is useful for positron emission tomography (PET) imaging, especially imaging prostate tumor. |
申请公布号 |
EP2993171(A1) |
申请公布日期 |
2016.03.09 |
申请号 |
EP20140183635 |
申请日期 |
2014.09.04 |
申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. |
发明人 |
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分类号 |
C07D213/81;A61K31/44;A61P35/00;C07C231/02;C07C275/16;C07D213/82;C07D231/14;C07D241/24 |
主分类号 |
C07D213/81 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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