发明名称 |
FURIN-KNOCKDOWN AND GM-CSF-AUGMENTED (FANG) CANCER VACCINE |
摘要 |
Compositions and methods for cancer treatment are disclosed herein. More specifically the present invention describes an autologous cancer vaccine genetically modified for Furin knockdown and GM-CSF expression. The vaccine described herein attenuates the immunosuppressive activity of TGF-&bgr; through the use of bi-functional shRNAs to knock down the expression of furin in cancer cells, and to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene. |
申请公布号 |
EP2515916(B1) |
申请公布日期 |
2016.03.09 |
申请号 |
EP20100840035 |
申请日期 |
2010.12.20 |
申请人 |
GRADALIS, INC. |
发明人 |
NEMUNAITIS, JOHN, J.;SENZER, NEIL;MAPLES, PHILLIP, B.;RAO, DONALD |
分类号 |
A61K31/7105;A61K31/711;A61P35/00 |
主分类号 |
A61K31/7105 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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