| 摘要 |
The present invention relates to a solid composition comprising a first component selected from the group consisting of chitosan, chitin, derivatives of chitosan, derivatives of chitin, and any combination thereof; at least one triprotic acid; and at least one solubilising acid. Preferably the triprotic acid is citric acid and the solubilising acid is a monoprotic acid such as lactic acid. Also claimed is a wound dressing comprising the composition and the use of the composition as a therapeutic agent and in the treatment of wounds. The composition may be used to disrupt and kill bacteria within a biofilm and also prevent biofilm formation. The method of manufacturing the composition comprises the steps of coating at least a portion of the first component with the at least one triprotic acid and the at least one solubilising acid and/or absorbing into at least a portion of the first component the at least one triprotic acid and the at least one solubilising acid. |
