| 摘要 |
An antibiotic-eluting medical device for implantation into a mammalian subject produced by an extrusion-based additive manufacturing process wherein an antibiotic composition is concurrently laid down with a polymeric material. One or more bone-growth-promoting compositions may be concurrently deposited with the polymeric material. The antibiotic-eluting medical device may be a temporary or a permanent orthopaedic skeletal component, an orthopaedic articulating joint replacement component, or an external hard-shell casing for an implantable device. The implantable device may be a cardiac pacemaker, a spinal cord stimulator, a neurostimulation system, an intrathecal drug pump for delivery of medicants into the spinal fluid, an insulin pump, an osmotic pump, a heparin pump, or an infusion pump for delivery of chemotherapeutics and/or anti-spasmodics. |
