| 发明名称 | Monoclonal antibody recognizing human papillomavirus (HPV) L2 protein and method for measuring HPV-neutralizing antibody titer using the same | ||
| 摘要 | The present invention relates to the development of a monoclonal antibody which has binding activity to many high-risk types of HPV, etc. The present invention also provides a simple and high-throughput method for measuring cross-neutralizing antibody titers, which is used for assay of cross-neutralizing antibody against HPV in serum samples from subjects, etc. The method of the present invention for measuring cross-neutralizing antibody titers comprises the steps of: preparing a monoclonal antibody against a peptide having a specific amino acid sequence common to high-risk types of HPV; and assaying cross-neutralizing antibody using this monoclonal antibody. | ||
| 申请公布号 | US9279161(B2) | 申请公布日期 | 2016.03.08 |
| 申请号 | US201113997902 | 申请日期 | 2011.12.26 |
| 申请人 | Japan Health Sciences Foundation | 发明人 | Mori Seiichiro;Kanda Tadahito |
| 分类号 | A61K39/42;C12Q1/70;C07K16/08;G01N33/574;A61K47/48;G01N33/569;A61K39/12;A61K39/00 | 主分类号 | A61K39/42 |
| 代理机构 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. | 代理人 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. ;Conlin, Esq. David G.;Clarke Daniel W. |
| 主权项 | 1. A monoclonal antibody which recognizes a common epitope in human papillomavirus L2 protein, said epitope consisting of SEQ ID NO: 2 or SEQ ID NO: 24, wherein said antibody comprises the amino acid sequences shown in SEQ ID NO: 11 (CDRH1), SEQ ID NO: 12 (CDRH2), SEQ ID NO: 13 (CDRH3), SEQ ID NO: 14 (CDRL1), SEQ ID NO: 15 (CDRL2) and SEQ ID NO: 16 (CDRL3). | ||
| 地址 | Tokyo JP | ||