THREE DIMENSIONAL TISSUE IMAGING SYSTEM AND METHOD

摘要

Multispectral digitized images are provided by utilizing 2 or more spectral bands, providing images and information regarding a pigmented or other differentiated tissue sample at differing depths. The images are transformed to enhance morphological patterns characteristic of melanoma, such as the statistical properties of the pigment network, image texture or homogeneity, and the lesion reflectance, in order to provide information about lesion morphology at different depths. The images can also be processed and transformed to extract features such as blood volume saturation, oxygen saturation, or other characteristics that can be identified based on differential reflectance or absorption of light.

主权项

1) A method of non-destructive imaging of an anomalous tissue in a region of interest, the method comprising:
a) illuminating the region of interest with light in a first spectral band, the first spectral band being associated with a predetermined first depth value in the tissue; b) capturing, with a camera, a first two-dimensional image of the region of interest under illumination by the light in the first spectral band; c) illuminating the region of interest with light in a second spectral band, the second spectral band of light being associated with a predetermined second depth value in the tissue; d) capturing, with the camera, a second two-dimensional image of the region of interest under illumination by the light in the second spectral band; e) processing the first image to define a first anomaly area comprised of a first set of data points, each having lateral position data defining a position within a first plane; f) processing the second image to define a second anomaly area comprised of a second set of data points, each having lateral position data defining a position within a second plane; g) transforming the first and second anomaly areas into a single three-dimensional anomaly volume by additionally applying the first depth value to each data point in the first set of data points and the second depth value to each data point in the second set of data points, yielding first and second transformed sets of data points, respectively, each data point within each of the first and second transformed sets of data points thereby having assigned lateral position and depth data; h) rendering an image of the three-dimensional anomaly volume by plotting the first and second transformed sets of data points; and i) displaying the rendered image to a user.