发明名称 |
Methods of enhancing drug delivery and effectiveness of therapeutic agents |
摘要 |
The present invention in one aspect provides methods of enhancing uptake of a therapeutic agent in a target tissue as well as methods of treating a disease (such as cancer) or enhancing effectiveness of treatment with a therapeutic agent in an individual by co-administering a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane with the therapeutic agent. The present invention in another aspect provides a method of treatment or a method of selecting patients for treatment of a disease (such as cancer) with the combination of a therapeutic agent and a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane based on one or more characteristics of the target tissue that correlates or indicates the capability of getting enhanced therapeutic agent uptake as a result of the co-administration of the taxane nanoparticle composition in the target tissue (referred to as "the drug uptake capability"). Also provided are pharmaceutical compositions, article of manufacture, and kits useful for methods described herein. |
申请公布号 |
AU2011232862(B2) |
申请公布日期 |
2016.03.03 |
申请号 |
AU20110232862 |
申请日期 |
2011.03.28 |
申请人 |
ABRAXIS BIOSCIENCE, LLC |
发明人 |
DESAI, NEIL P.;SOON-SHIONG, PATRICK |
分类号 |
A61K31/337;A61K9/14;A61P35/00 |
主分类号 |
A61K31/337 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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